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Targeted Allele Detail
Symbol: Tyk2tm1Biat
Name: tyrosine kinase 2; targeted mutation 1, Biomodels Austria
MGI ID: MGI:5438711
Gene: Tyk2  Location: Chr9:21104068-21131243 bp, - strand  Genetic Position: Chr9, 7.71 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:65408
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo cassette replaced most of the exons encoding the Jak homology (JH) domains JH7 (partly), JH6/5 and JH4 (partly). Western blot analysis confirmed the absence of protein expression in bone marrow macrophage. (J:65408)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyk2 Mutation:  48 strains or lines available
Original:  J:65408 Karaghiosoff M, et al., Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity. 2000 Oct;13(4):549-60
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory