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Targeted Allele Detail
Symbol: Kdm6atm1b(EUCOMM)Jhha
Name: lysine (K)-specific demethylase 6A; targeted mutation 1b, Jacob H Hanna
MGI ID: MGI:5438705
Synonyms: Utxdelta
Gene: Kdm6a  Location: ChrX:18162575-18279936 bp, + strand  Genetic Position: ChrX, 13.45 cM
Germline Transmission:  Earliest citation of germline transmission: J:186686
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe targeting vector from EUCOMM was used to insert an FRT flanked lacZ and neo cassette and a loxP site upstream of exon 3 and a second loxP site downstream of exon 3 via homologous recombination. Cre mediated recombination deleted exon 3. (J:186686)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:  38 strains or lines available
In J:186686, the targeting construct was injected into V6.5 ES cells [(C57BL/6 x 129S4/SvJae)F1], V19-OSKM ES cells [(C57BL/6 x 129S4/SvJae)F1], and BVSC ES cells [(C57BL/6 x DBA)F2].
Original:  J:186686 Mansour AA, et al., The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature. 2012 Aug 16;488(7411):409-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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