Nos3^tm1.1Taka
Targeted Allele Detail

Summary

• Symbol: Nos3^tm1.1Taka
• Name: nitric oxide synthase 3, endothelial cell; targeted mutation 1.1, Takamune Takahashi
• MGI ID: MGI:5438593
• Synonyms: Nos3^flox(F1)
• Gene: Nos3 Location: Chr5:24569808-24589472 bp, + strand Genetic Position: Chr5, 11.32 cM
• Alliance: Nos3^tm1.1Taka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187860
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 9. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the neo cassette and left exons 9 through 12 floxed. (J:187860)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nos3 Mutation: 56 strains or lines available

References

• Original: J:187860 Jiang R, et al., Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene. Genesis. 2012 Sep;50(9):685-92
• All: 3 reference(s)