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Tmeff2tm1Fawa
Targeted Allele Detail
Nomenclature
Symbol: Tmeff2tm1Fawa
Name: transmembrane protein with EGF-like and two follistatin-like domains 2; targeted mutation 1, Fan Wang
MGI ID: MGI:5438565
Synonyms: Tmeff2PLAP
Gene: Tmeff2  Location: Chr1:50900683-51187270 bp, + strand  Genetic Position: Chr1, 25.95 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187163
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct including a cDNA encoding human ALPP and a floxed neo cassette was inserted after the initiation codon replacing the rest of exon 1. In situ hybridization confirmed the absence of mRNA expression in homozygous embryos. (J:187163)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tmeff2 Mutation:  2 strains or lines available
References
Original:  J:187163 Chen TR, et al., Generation and characterization of Tmeff2 mutant mice. Biochem Biophys Res Commun. 2012 Aug 24;425(2):189-94
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory