About   Help   FAQ
Idh1tm2Mak
Targeted Allele Detail
Nomenclature
Symbol: Idh1tm2Mak
Name: isocitrate dehydrogenase 1 (NADP+), soluble; targeted mutation 2, Tak Mak
MGI ID: MGI:5438253
Synonyms: Idh1LSL
Gene: Idh1  Location: Chr1:65158616-65186479 bp, - strand  Genetic Position: Chr1, 32.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186700
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA floxed neo/STOP cassette was inserted upstream of a modified exon 4 in which nucleotide substitution results in the amino acid substitution of histidine for arginine at position 132 (R132H). (J:186700)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Idh1 Mutation:  8 strains or lines available
References
Original:  J:186700 Sasaki M, et al., IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 2012 Aug 30;488(7413):656-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2020
MGI 6.15
The Jackson Laboratory