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Slc39a4tm2Gka
Targeted Allele Detail
Nomenclature
Symbol: Slc39a4tm2Gka
Name: solute carrier family 39 (zinc transporter), member 4; targeted mutation 2, Glen K Andrews
MGI ID: MGI:5438020
Synonyms: Zip4FX
Gene: Slc39a4  Location: Chr15:76612383-76617379 bp, - strand  Genetic Position: Chr15, 36.16 cM
Growth retardation of tamoxifen treated Slc39a4tm2Gka/Slc39a4tm2Gka Tg(Vil-cre/ERT2)23Syr/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187178
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site and flanking XhoI restriction site were introduced in intron 5 and a loxP site and mc1-neo cassette were introduced downstream of the last exon via homologous recombination. (J:187178)
Generation of the Slc39a4tm2Gka allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc39a4 Mutation:  6 strains or lines available
References
Original:  J:187178 Geiser J, et al., A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. PLoS Genet. 2012 Jun;8(6):e1002766
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory