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Targeted Allele Detail
Symbol: Slc39a4tm2Gka
Name: solute carrier family 39 (zinc transporter), member 4; targeted mutation 2, Glen K Andrews
MGI ID: MGI:5438020
Synonyms: Zip4FX
Gene: Slc39a4  Location: Chr15:76612385-76616852 bp, - strand  Genetic Position: Chr15, 36.16 cM
Growth retardation of tamoxifen treated Slc39a4tm2Gka/Slc39a4tm2Gka Tg(Vil-cre/ERT2)23Syr/0 mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:187178
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site and flanking XhoI restriction site were introduced in intron 5 and a loxP site and mc1-neo cassette were introduced downstream of the last exon via homologous recombination. (J:187178)
Generation of the Slc39a4tm2Gka allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc39a4 Mutation:  17 strains or lines available
Original:  J:187178 Geiser J, et al., A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. PLoS Genet. 2012 Jun;8(6):e1002766
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory