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Pabpc1ltm1.1Esel
Targeted Allele Detail
Nomenclature
Symbol: Pabpc1ltm1.1Esel
Name: poly(A) binding protein, cytoplasmic 1-like; targeted mutation 1.1, Emre Seli
MGI ID: MGI:5437740
Gene: Pabpc1l  Location: Chr2:164025450-164050538 bp, + strand  Genetic Position: Chr2, 84.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187525
Parent Cell Line:  S1B6 (ES Cell)
Strain of Origin:  129S1/SvImJ or C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced exon 2. Cre-mediated recombination removed the neo cassette. RT-PCR confirmed the absence of protein expression in ovaries. (J:187525)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pabpc1l Mutation:  24 strains or lines available
References
Original:  J:187525 Guzeloglu-Kayisli O, et al., Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochem J. 2012 Aug 15;446(1):47-58
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/15/2020
MGI 6.15
The Jackson Laboratory