Camkk2^tm1Shyy
Targeted Allele Detail

Summary

• Symbol: Camkk2^tm1Shyy
• Name: calcium/calmodulin-dependent protein kinase kinase 2, beta; targeted mutation 1, John Y J Shyy
• MGI ID: MGI:5437264
• Synonyms: CaMKKbeta^-
• Gene: Camkk2 Location: Chr5:122869233-122917472 bp, - strand Genetic Position: Chr5, 62.55 cM
• Alliance: Camkk2^tm1Shyy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187027
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 2 through 5. Western blot analysis confirmed the absence of protein expression in the epididymal fat pad. (J:187027)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camkk2 Mutation: 43 strains or lines available

References

• Original: J:187027 Peng IC, et al., Glucagon regulates ACC activity in adipocytes through the CAMKKbeta/AMPK pathway. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1560-8
• All: 1 reference(s)