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Sox7tm1.1Dsco
Targeted Allele Detail
Summary
Symbol: Sox7tm1.1Dsco
Name: SRY (sex determining region Y)-box 7; targeted mutation 1.1, Daryl A Scott
MGI ID: MGI:5437221
Synonyms: Sox7-
Gene: Sox7  Location: Chr14:64181155-64188181 bp, + strand  Genetic Position: Chr14, 33.34 cM, cytoband C3
Alliance: Sox7tm1.1Dsco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187416
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed exon 2 and the neo cassette. (J:187416)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox7 Mutation:  21 strains or lines available
References
Original:  J:187416 Wat MJ, et al., Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1. Hum Mol Genet. 2012 Sep 15;21(18):4115-25
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory