Khk^tm2.1Dtb
Targeted Allele Detail

Summary

• Symbol: Khk^tm2.1Dtb
• Name: ketohexokinase; targeted mutation 2.1, David T Bonthron
• MGI ID: MGI:5435942
• Synonyms: Khk-N^tm1.1Ls
• Gene: Khk Location: Chr5:31078780-31088592 bp, + strand Genetic Position: Chr5, 16.9 cM
• Alliance: Khk^tm2.1Dtb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169366
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A stop codon was introduced into exon 3a preventing the production of the A transcript. A floxed neo cassette was inserted upstream of the modified exon 3a. Exons 4 through 6 and part of 7 were deleted, preventing the expression of the C splice variant. Cre-mediated recombination removed the neo cassette. (J:169366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Khk Mutation: 25 strains or lines available

References

• Original: J:169366 MouseBook^TM, Information obtained from MouseBook^TM, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished. 2005-2013
• All: 8 reference(s)