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Shank2tm1.1Tmb
Targeted Allele Detail
Nomenclature
Symbol: Shank2tm1.1Tmb
Name: SH3 and multiple ankyrin repeat domains 2; targeted mutation 1.1, Tobias M Boeckers
MGI ID: MGI:5435698
Synonyms: Shank2-
Gene: Shank2  Location: Chr7:144001928-144424494 bp, + strand  Genetic Position: Chr7, 88.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186719
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 7 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 7 via homologous recombination. Recombinase mediated recombination deleted exon 7 and the neo cassette. (J:186719)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shank2 Mutation:  53 strains or lines available
References
Original:  J:186719 Schmeisser MJ, et al., Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 2012 Jun 14;486(7402):256-60
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory