Kcnn3^tm2.1Jpad
Targeted Allele Detail

Summary

• Symbol: Kcnn3^tm2.1Jpad
• Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; targeted mutation 2.1, John P Adelman
• MGI ID: MGI:5435580
• Synonyms: SK3^flox
• Gene: Kcnn3 Location: Chr3:89427471-89579801 bp, + strand Genetic Position: Chr3, 39.16 cM, cytoband F2
• Alliance: Kcnn3^tm2.1Jpad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187145
• Parent Cell Line: Duffy (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of the translation initiation codon in exon 1. A frt-flanked neomycin resistance (neo) cassette and a second loxP site were inserted downstream of exon 1. Heterozygous mice were bred with Flp transgenic mice to delete the neo cassette. (J:187145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnn3 Mutation: 51 strains or lines available

References

• Original: J:187145 Deignan J, et al., SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. 2012 Aug 16;217:67-76
• All: 7 reference(s)