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Krt17tm1(cre,Cerulean)Murr
Targeted Allele Detail
Nomenclature
Symbol: Krt17tm1(cre,Cerulean)Murr
Name: keratin 17; targeted mutation 1, Steve Murray
MGI ID: MGI:5435552
Gene: Krt17  Location: Chr11:100256217-100261029 bp, - strand  Genetic Position: Chr11, 63.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187143
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace the stop codon of the endogenous keratin 17 (Krt17) gene with (from 5' to 3') a viral 2A oligopeptide (to mediate ribosomal skipping), cre recombinase, another 2A oligopeptide, the cerulean variant of green fluorescent protein (GFP), and a bovine polyadenylation sequence. This sequence was followed by a frt-flanked neomycin (neo) resistance cassette. This construct was electroporated into C57BL/6NTac derived JM8A3 embryonic stem (ES) cells. (J:187143)
Recombinase
activity
Activity:
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Driver: Krt17     Summary of all recombinase alleles driven by Krt17. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt17 Mutation:  22 strains or lines available
References
Original:  J:187143 Murray S, Generation of a keratin 17 cre/cerulean knock-in allele. MGI Direct Data Submission. 2012;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory