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Targeted Allele Detail
Symbol: Axin2tm1(cre/ERT2)Rnu
Name: axin 2; targeted mutation 1, Roel Nusse
MGI ID: MGI:5433373
Synonyms: Axin2creERT2
Gene: Axin2  Location: Chr11:108920349-108950783 bp, + strand  Genetic Position: Chr11, 71.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:186834
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intergenic deletion
Mutation detailsA cre/ERT2 sequence (cre recombinase fused to a G400V/M543A/L544A triple mutation ofthe human estrogen receptor ligand binding domain) and an FRT-flanked puromycin resistance cassette were knocked into exon 2 of the Axin2 gene. Transient flp expression in ES cells and crosses to flp-expressing strains were unsuccessful at excising the selection cassette, but its presence does not seem to have negative side effects. (J:74286, J:186834)
 Tissue activity of this recombinase allele
Driver: Axin2     Summary of all recombinase alleles driven by Axin2.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Axin2 Mutation:  27 strains or lines available
Original:  J:186834 van Amerongen R, et al., Developmental Stage and Time Dictate the Fate of Wnt/beta-Catenin-Responsive Stem Cells in the Mammary Gland. Cell Stem Cell. 2012 Sep 7;11(3):387-400
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory