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Grm1Tg(p18A4.B)1352Szc
Transgenic Allele Detail
Nomenclature
Symbol: Grm1Tg(p18A4.B)1352Szc
Name: glutamate receptor, metabotropic 1; transgene insertion 1352, Suzie Chen
MGI ID: MGI:5432227
Synonyms: TG3
Gene: Grm1  Location: Chr10:10686059-11082356 bp, - strand  Genetic Position: Chr10, 3.44 cM, cytoband A2
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe transgene contained a 2 kb segment of human cosmid p18A4 (known as Clone B; abbreviated here as p18A4.B). Line 1352 contains 3 copies of the transgene that insert into intron 3 and result in a 70 kb deletion within intron 3. Western blot analysis confirmed ectopic expression in melanoma tumors. (J:11894, J:83183)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grm1 Mutation:  47 strains or lines available
References
Original:  J:32786 Chen S, et al., Spontaneous melanocytosis in transgenic mice. J Invest Dermatol. 1996 May;106(5):1145-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory