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Tg(CAG-Cfh*)#Mcp
Transgene Detail
Nomenclature
Symbol: Tg(CAG-Cfh*)#Mcp
Name: transgene insertion, Matthew C Pickering
MGI ID: MGI:5432032
Synonyms: FHdelta16-20
Transgene: Tg(CAG-Cfh*)#Mcp  Location: unknown  
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-Cfh*)#Mcp expresses 1 gene
 
Mutation detailsA modified version of the CAGGS promoter drives expression of a mouse Cfh gene with a Cys937Stop mutation resulting in a truncated protein that lacks the terminal five SCR domains. The truncated protein is detected in the plasma at levels comparable to the wild-type protein. The truncated protein retained complement regulatory activity but showed impaired binding to heparin and human umbilical vein endothelial cells in vitro. (J:125860)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:125860 Pickering MC, et al., Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med. 2007 Jun 11;204(6):1249-56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory