Grin2b^tm1Mony
Targeted Allele Detail

Summary

• Symbol: Grin2b^tm1Mony
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1, Hannah Monyer
• MGI ID: MGI:5432023
• Synonyms: NR2B^2lox
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^tm1Mony page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186311
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 9. An additional loxP site and FRT-flanked neo cassette were inserted downstream of exon 9. (J:186311)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 96 strains or lines available

References

• Original: J:186311 von Engelhardt J, et al., Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks. Neuron. 2008 Dec 10;60(5):846-60
• All: 13 reference(s)