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Tg(CD207-cre/ERT2)1Dhka
Transgene Detail
Nomenclature
Symbol: Tg(CD207-cre/ERT2)1Dhka
Name: transgene insertion 1, Daniel H Kaplan
MGI ID: MGI:5431679
Synonyms: huLangerin-CreERT2
Transgene: Tg(CD207-cre/ERT2)1Dhka  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA cassette encoding an IRES-cre/ERT2 sequence was inserted in the 3' UTR of the human langerin (CD207) gene in the bacterial artificial chromosome (BAC) RP11-504O1 by homologous recombination. This generated a 61 kb fragment that was used to produce transgenic mice. (J:185586)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: CD207     Summary of all recombinase alleles driven by CD207.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:185586 Bobr A, et al., Autocrine/paracrine TGF-beta1 inhibits Langerhans cell migration. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10492-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory