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Tg(Erv4-cre/ERT2*)657Slp
Transgene Detail
Nomenclature
Symbol: Tg(Erv4-cre/ERT2*)657Slp
Name: transgene insertion 657, Samuel L Pfaff
MGI ID: MGI:5431581
Synonyms: 2C::ERT2-Cre-ERT2, Tg(MuERV-L-ERT2-Cre-ERT2)657Slp
Transgene: Tg(Erv4-cre/ERT2*)657Slp  Location: unknown  
Transgene
origin
Strain of Origin:  BALB/c and C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe 5' LTR of murine endogenous retrovirus with leucine tRNA primer (MuERV-L; MERVL; Erv4) and the primer binding site drive expression of tamoxifen-inducible Cre recombinase (2C::ERT2-Cre-ERT2). Two flanking ERT2 segments were inserted to make Cre activation less leaky. The transgenic vector was injected into CB6 (BALB/c and C57BL/6) embryos and the resultant strain was subsequently maintained on the same mixed genetic background by the donating laboratory. This is founder line 657. (J:186302)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Erv4     Summary of all recombinase alleles driven by Erv4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:186302 Macfarlan TS, et al., Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature. 2012 Jul 5;487(7405):57-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory