Ncr1^tm2.1Viv
Targeted Allele Detail

Summary

• Symbol: Ncr1^tm2.1Viv
• Name: natural cytotoxicity triggering receptor 1; targeted mutation 2.1, Eric Vivier
• MGI ID: MGI:5430925
• Synonyms: NKLT^-
• Gene: Ncr1 Location: Chr7:4340723-4348163 bp, + strand Genetic Position: Chr7, 2.5 cM
• Alliance: Ncr1^tm2.1Viv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186000
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An EGFP and floxed neo cassette were inserted downstream of the stop codon. Cre-mediated recombination removed the neo cassette. (J:186000)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncr1 Mutation: 39 strains or lines available

References

• Original: J:186000 Guia S, et al., Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci Signal. 2011;4(167):ra21
• All: 1 reference(s)