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Rdh10tm1c(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Rdh10tm1c(KOMP)Wtsi
Name: retinol dehydrogenase 10 (all-trans); targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5429723
Synonyms: Rdh10fl, Rdh10flox
Gene: Rdh10  Location: Chr1:16176106-16202774 bp, + strand  Genetic Position: Chr1, 4.94 cM
Mutation
origin
Mutant Cell Line:  EPD0149_1_D08
Germline Transmission:  Earliest citation of germline transmission: J:185330
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 16097421 of Chromosome 1 upstream of exon 2 (Build 37). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 2 at position 16098357. The critical exon(s) is/are thus flanked by loxP sites. Flp mediated recombination removed the lacZ and neo cassettes leaving exon 2 floxed. (J:148605, J:173534, J:185330)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rdh10 Mutation:  16 strains or lines available
Notes
J:185330 used EPD0149_1_D08 ES cells
References
Original:  J:185330 Sandell LL, et al., RDH10 oxidation of Vitamin A is a critical control step in synthesis of retinoic acid during mouse embryogenesis. PLoS One. 2012;7(2):e30698
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory