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Transgene Detail
Symbol: Tg(Pklr-SV40)1Ak
Name: transgene insertion 1, Axel Kahn
MGI ID: MGI:5429578
Synonyms: L-PK/Tag1
Transgene: Tg(Pklr-SV40)1Ak  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThis transgene consists of the SV40 early genes including the coding sequence of the transforming large tumor and small tumor antigens under the control of the rat L-type pyruvate kinase gene regulatory region. Transcription of Pklr is dependent on metabolic and hormonal controls such that glucose and insulin increase transcription while fasting, refeeding a low-carbohydrate diet and glucagon inhibit Pklr transcription. Thus manipulation of diet can result in expression of the transgene. Three lines were established with different transgene copy number (Lines 1,2,3). Line 1 carries approximately 100 copies of the transgene. Northern blot analysis indicates transgene expression in the liver and to a lesser degree in the small intestine, kidney, and pancreas. (J:185488)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:185488 Cartier N, et al., Diet-dependent carcinogenesis of pancreatic islets and liver in transgenic mice expressing oncogenes under the control of the L-type pyruvate kinase gene promoter. Oncogene. 1992 Jul;7(7):1413-22
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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