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Targeted Allele Detail
Symbol: Aim2tm1.1Vmd
Name: absent in melanoma 2; targeted mutation 1.1, Vishva M Dixit
MGI ID: MGI:5428935
Gene: Aim2  Location: Chr1:173178445-173293606 bp, + strand  Genetic Position: Chr1, 80.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:160545
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 5 and a neo cassette and loxP site were inserted downstream of exon 5. Cre mediated recombination deleted exon 5 and the neo cassette. Western blot analysis confirmed the absence of gene expression in bone marrow derived macrophages from homozygous mice. (J:160545)
Generation of the Aim2tm1.1Vmd allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aim2 Mutation:  21 strains or lines available
Original:  J:160545 Jones JW, et al., Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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