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Aim2tm1.1Vmd
Targeted Allele Detail
Nomenclature
Symbol: Aim2tm1.1Vmd
Name: absent in melanoma 2; targeted mutation 1.1, Vishva M Dixit
MGI ID: MGI:5428935
Gene: Aim2  Location: Chr1:173178445-173293606 bp, + strand  Genetic Position: Chr1, 80.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160545
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NCrl
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 5 and a neo cassette and loxP site were inserted downstream of exon 5. Cre mediated recombination deleted exon 5 and the neo cassette. Western blot analysis confirmed the absence of gene expression in bone marrow derived macrophages from homozygous mice. (J:160545)
Generation of the Aim2tm1.1Vmd allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aim2 Mutation:  20 strains or lines available
References
Original:  J:160545 Jones JW, et al., Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9771-6
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory