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Hprttm1(Nphs1-CMIP)Dsah
Targeted Allele Detail
Nomenclature
Symbol: Hprttm1(Nphs1-CMIP)Dsah
Name: hypoxanthine guanine phosphoribosyl transferase; targeted mutation 1, Djillali Sahali
MGI ID: MGI:5428689
Gene: Hprt  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185411
Parent Cell Line:  BPES (ES Cell)
Strain of Origin:  (129-Hprtb-m3 x C57BL/6)F1
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Hprttm1(Nphs1-CMIP)Dsah expresses 1 gene
 
Mutation detailsA transgene containing the mouse promoter driving podocyte-specifc expression of the human cDNA with a human HPRT sequence for selection was targeted to the locus. (J:185411)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt Mutation:  1275 strains or lines available
References
Original:  J:185411 Zhang SY, et al., c-mip impairs podocyte proximal signaling and induces heavy proteinuria. Sci Signal. 2010;3(122):ra39
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory