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Pcsk7tm1Rob
Targeted Allele Detail
Nomenclature
Symbol: Pcsk7tm1Rob
Name: proprotein convertase subtilisin/kexin type 7; targeted mutation 1, Elizabeth Robertson
MGI ID: MGI:5428017
Gene: Pcsk7  Location: Chr9:45906497-45929726 bp, + strand  Genetic Position: Chr9, 25.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78623
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExons 3 through 7 were deleted, including sequences encoding the translational start site, the pro region, and the entirecatalytic domain of PC7. (J:78623, J:227651)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcsk7 Mutation:  4 strains or lines available
References
Original:  J:78623 Villeneuve P, et al., Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. J Neurochem. 2002 Aug;82(4):783-93
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory