Gt(ROSA)26Sortm596(Htt*145Q)Arte
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm596(Htt*145Q)Arte |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 596, TaconicArtemis |
MGI ID: |
MGI:5428009 |
Synonyms: |
Gt(ROSA)26Sor tm596Arte |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm596(Htt*145Q)Arte page
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Germline Transmission: |
Earliest citation of germline transmission:
J:184973
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Inserted expressed sequence, RMCE-ready) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm596(Htt*145Q)Arte expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Htt (MGI:96067) |
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Mutation details: An Htt with a 145 glutamine stretch, Htt154Q(1-586), was inserted into the locus via recombinase mediated cassette exchange (RMCE).
(J:184973)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
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Original: |
J:184973 Gafni J, et al., Caspase-6 Activity in a BACHD Mouse Modulates Steady-State Levels of Mutant Huntingtin Protein But Is Not Necessary for Production of a 586 Amino Acid Proteolytic Fragment. J Neurosci. 2012 May 30;32(22):7454-7465 |
All: |
1 reference(s) |
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