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Wnk4tm1Pfi
Targeted Allele Detail
Nomenclature
Symbol: Wnk4tm1Pfi
Name: WNK lysine deficient protein kinase 4; targeted mutation 1, Pfizer, Ltd
MGI ID: MGI:5427702
Gene: Wnk4  Location: Chr11:101260567-101277409 bp, + strand  Genetic Position: Chr11, 64.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184790
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment, consisting of 75 bp 5' of exon 1, all of exon 1 and 737 bp 3' of exon 1, was replaced with a neo cassette via homologous recombination. Real time PCR and western blot analyses confirmed the absence of expression in homozygous mice. (J:184790)
Generation of the Wnk4tm1Pfi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnk4 Mutation:  28 strains or lines available
Notes
ES cell line = TG-ES01-01 ESM07
References
Original:  J:184790 Castaneda-Bueno M, et al., Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7929-34
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory