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Targeted Allele Detail
Symbol: Wnk4tm1Pfi
Name: WNK lysine deficient protein kinase 4; targeted mutation 1, Pfizer, Ltd
MGI ID: MGI:5427702
Gene: Wnk4  Location: Chr11:101260567-101277409 bp, + strand  Genetic Position: Chr11, 64.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:184790
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment, consisting of 75 bp 5' of exon 1, all of exon 1 and 737 bp 3' of exon 1, was replaced with a neo cassette via homologous recombination. Real time PCR and western blot analyses confirmed the absence of expression in homozygous mice. (J:184790)
Generation of the Wnk4tm1Pfi allele
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnk4 Mutation:  4 strains or lines available
ES cell line - TG-ES01-01 ESM07

Original:  J:184790 Castaneda-Bueno M, et al., Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7929-34
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory