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Ctc1tm1.1Schg
Targeted Allele Detail
Nomenclature
Symbol: Ctc1tm1.1Schg
Name: CTS telomere maintenance complex component 1; targeted mutation 1.1, Sandy Chang
MGI ID: MGI:5427642
Gene: Ctc1  Location: Chr11:69015911-69036473 bp, + strand  Genetic Position: Chr11, 42.29 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184809
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the neo cassette and exon 6. The predicted truncated product lacks domain necessary for protein protein interaction. (J:184809)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctc1 Mutation:  82 strains or lines available
References
Original:  J:184809 Gu P, et al., CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 2012 May 16;31(10):2309-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory