Ctc1^tm1Schg
Targeted Allele Detail

Summary

• Symbol: Ctc1^tm1Schg
• Name: CTS telomere maintenance complex component 1; targeted mutation 1, Sandy Chang
• MGI ID: MGI:5427641
• Synonyms: CTC1^F
• Gene: Ctc1 Location: Chr11:68906737-68927299 bp, + strand Genetic Position: Chr11, 42.29 cM, cytoband B3
• Alliance: Ctc1^tm1Schg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184809
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette with a 5' loxP site was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 6. (J:184809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctc1 Mutation: 99 strains or lines available

References

• Original: J:184809 Gu P, et al., CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 2012 May 16;31(10):2309-21
• All: 1 reference(s)