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Bscl2tm1.1Lchan
Targeted Allele Detail
Nomenclature
Symbol: Bscl2tm1.1Lchan
Name: Berardinelli-Seip congenital lipodystrophy 2 homolog (seipin); targeted mutation 1.1, Lawrence Chan
MGI ID: MGI:5426998
Synonyms: Bscl2neofldelta3
Gene: Bscl2  Location: Chr19:8837687-8848667 bp, + strand  Genetic Position: Chr19, 5.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183701
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination of Bscl2tm1Lchan removed exon 3. qPCR confirmed the absence of transcript in epididymal white adipose tissue, subcutaneous white adipose tissue and brown adipose tissue. (J:183701)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bscl2 Mutation:  5 strains or lines available
References
Original:  J:183701 Chen W, et al., Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation. Mol Cell Biol. 2012 Mar;32(6):1099-111
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory