Soat2^tm1Llr
Targeted Allele Detail

Summary

• Symbol: Soat2^tm1Llr
• Name: sterol O-acyltransferase 2; targeted mutation 1, Lawrence L Rudel
• MGI ID: MGI:5426948
• Synonyms: Acat2^tm1Lrud, Soat2^tm1Lrud
• Gene: Soat2 Location: Chr15:102058961-102071904 bp, + strand Genetic Position: Chr15, 57.33 cM
• Alliance: Soat2^tm1Llr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184908
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: An FRT and loxP flanked neo cassette was inserted upstream of exon 11. An additionally loxP site was inserted downstream of exon 13. Enzymatic assay confirmed less than 10% normal activity levels. This allele is severely hypomorphic. (J:184908)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Soat2 Mutation: 37 strains or lines available

References

• Original: J:184908 Zhang J, et al., Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res. 2012 Jun;53(6):1144-52
• All: 1 reference(s)