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Itgb2tm1.1Mskim
Targeted Allele Detail
Nomenclature
Symbol: Itgb2tm1.1Mskim
Name: integrin beta 2; targeted mutation 1.1, Minsoo Kim
MGI ID: MGI:5426359
Synonyms: CD18-mCFP
Gene: Itgb2  Location: Chr10:77530329-77565681 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184820
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsmCFP was fused to the last exon (exon 16) along with a 6 amino acid linker (GGPVAT) and a loxP-flanked neomycin resistance cassette. Cre-mediated recombination removed the neo cassette. (J:184820)
Generation of the Itgb2tm1.1Mskim allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  8 strains or lines available
References
Original:  J:184820 Hyun YM, et al., Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med. 2012 Jul 2;209(7):1349-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory