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Targeted Allele Detail
Symbol: Itgb2tm1.1Mskim
Name: integrin beta 2; targeted mutation 1.1, Minsoo Kim
MGI ID: MGI:5426359
Synonyms: CD18-mCFP
Gene: Itgb2  Location: Chr10:77530329-77565708 bp, + strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:184820
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsmCFP was fused to the last exon (exon 16) along with a 6 amino acid linker (GGPVAT) and a loxP-flanked neomycin resistance cassette. Cre-mediated recombination removed the neo cassette. (J:184820)
Generation of the Itgb2tm1.1Mskim allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  9 strains or lines available
Original:  J:184820 Hyun YM, et al., Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med. 2012 Jul 2;209(7):1349-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory