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Targeted Allele Detail
Symbol: Rapgef3tm1Geno
Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1, Genoway
MGI ID: MGI:5425762
Synonyms: EPAC1fs+/+
Gene: Rapgef3  Location: Chr15:97744770-97767972 bp, - strand  Genetic Position: Chr15, 53.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:182701
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe targeting vector was designed to insert a loxP site upstream of exon 3, followed by an frt-flanked neomycin cassette, and a second loxP site downstream of exon 6. The vector contained a 6.3 kb long homology arm and a 1.6 kb short homology arm. (J:182701)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rapgef3 Mutation:  29 strains or lines available
Original:  J:182701 Yang Y, et al., EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron. 2012 Feb 23;73(4):774-88
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory