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Targeted Allele Detail
Symbol: Mtortm1.2Seq
Name: mechanistic target of rapamycin kinase; targeted mutation 1.2, Susan E Quaggin
MGI ID: MGI:5425404
Synonyms: Mtordel
Gene: Mtor  Location: Chr4:148448611-148557683 bp, + strand  Genetic Position: Chr4, 78.76 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:184667
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon1 and an FRT flanked PGK-neo cassette followed by a second loxP site was inserted in intron 3. The selection cassette was removed from properly targeted mice using flp recombinase leaving exons 1-3 flanked by loxP sites. Exons 1-2 were then removed by cre excision. (J:184667)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtor Mutation:  11 strains or lines available
Original:  J:184667 Cina DP, et al., Inhibition of MTOR disrupts autophagic flux in podocytes. J Am Soc Nephrol. 2012 Mar;23(3):412-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory