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Ddah1tm1.1Yjch
Targeted Allele Detail
Nomenclature
Symbol: Ddah1tm1.1Yjch
Name: dimethylarginine dimethylaminohydrolase 1; targeted mutation 1.1, Yingjie Chen
MGI ID: MGI:5424370
Synonyms: DDAH1-
Gene: Ddah1  Location: Chr3:145758692-145894277 bp, + strand  Genetic Position: Chr3, 70.63 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182373
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 4 was deleted from Ddah1tm1Yjch by germline cre-mediated recombination. No encoded protein was detected in tissue samples from kidney, brain, liver and lung of homozygous animals. (J:182373)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddah1 Mutation:  6 strains or lines available
References
Original:  J:182373 Hu X, et al., Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1540-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory