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Targeted Allele Detail
Symbol: Egfrtm1.1Tyj
Name: epidermal growth factor receptor; targeted mutation 1.1, Tyler Jacks
MGI ID: MGI:5320891
Synonyms: Egfrtm1.1(L858R)Tyj
Gene: Egfr  Location: Chr11:16702203-16868158 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  V26.2 (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
Mutation detailsThe targeting construct introduced an FRT-neo-FRT cassette into intron 20 and a T->G point mutation in exon 21. The point mutation resulted in the amino acid substitution of arginine for lysine at position 858 (L858R). The locus was re-targeted to place a lox-Stop-lox (LSL) cassette in intron 1. Flp-mediated recombination removed the neo cassette. (J:101977)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:  67 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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