About   Help   FAQ
Egfrtm1.1Tyj
Targeted Allele Detail
Nomenclature
Symbol: Egfrtm1.1Tyj
Name: epidermal growth factor receptor; targeted mutation 1.1, Tyler Jacks
MGI ID: MGI:5320891
Synonyms: Egfrtm1.1(L858R)Tyj
Gene: Egfr  Location: Chr11:16702203-16868158 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  V26.2 (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation detailsThe targeting construct introduced an FRT-neo-FRT cassette into intron 20 and a T->G point mutation in exon 21. The point mutation resulted in the amino acid substitution of arginine for lysine at position 858 (L858R). The locus was re-targeted to place a lox-Stop-lox (LSL) cassette in intron 1. Flp-mediated recombination removed the neo cassette. (J:101977)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:  66 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory