Jak2^tm1Mohi
Targeted Allele Detail

Summary

• Symbol: Jak2^tm1Mohi
• Name: Janus kinase 2; targeted mutation 1, M Golam Mohi
• MGI ID: MGI:5320677
• Synonyms: Jak2^V617F
• Gene: Jak2 Location: Chr19:29229228-29290480 bp, + strand Genetic Position: Chr19, 23.73 cM
• Alliance: Jak2^tm1Mohi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184283
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 13 was replaced with a loxP site cDNA encoding exons 13 through 24, neo/STOP cassette, loxP site and modified exon 13 in which nucleotide substitutions result in the the amino acid substitution of phenylalanine for valine at position 617 (V617F). (J:184283)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jak2 Mutation: 57 strains or lines available

References

• Original: J:184283 Akada H, et al., Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 2010 Apr 29;115(17):3589-97
• All: 7 reference(s)