About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Jak2tm1Mohi
Name: Janus kinase 2; targeted mutation 1, M Golam Mohi
MGI ID: MGI:5320677
Synonyms: Jak2V617F
Gene: Jak2  Location: Chr19:29251828-29313080 bp, + strand  Genetic Position: Chr19, 23.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:184283
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 13 was replaced with a loxP site cDNA encoding exons 13 through 24, neo/STOP cassette, loxP site and modified exon 13 in which nucleotide substitutions result in the the amino acid substitution of phenylalanine for valine at position 617 (V617F). (J:184283)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jak2 Mutation:  5 strains or lines available
Original:  J:184283 Akada H, et al., Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 2010 Apr 29;115(17):3589-97
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory