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Targeted Allele Detail
Symbol: Jak2tm1Mohi
Name: Janus kinase 2; targeted mutation 1, M Golam Mohi
MGI ID: MGI:5320677
Synonyms: Jak2V617F
Gene: Jak2  Location: Chr19:29251828-29313080 bp, + strand  Genetic Position: Chr19, 23.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:184283
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 13 was replaced with a loxP site cDNA encoding exons 13 through 24, neo/STOP cassette, loxP site and modified exon 13 in which nucleotide substitutions result in the the amino acid substitution of phenylalanine for valine at position 617 (V617F). (J:184283)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jak2 Mutation:  26 strains or lines available
Original:  J:184283 Akada H, et al., Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease. Blood. 2010 Apr 29;115(17):3589-97
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory