Frzb^tm1.1Fplu
Targeted Allele Detail

Summary

• Symbol: Frzb^tm1.1Fplu
• Name: frizzled-related protein; targeted mutation 1.1, Frank P Luyten
• MGI ID: MGI:5320664
• Gene: Frzb Location: Chr2:80242314-80277740 bp, - strand Genetic Position: Chr2, 48.13 cM
• Alliance: Frzb^tm1.1Fplu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184281
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was floxed and an FRT flanked neo cassette was inserted downstream of exon 1 via homologous recombination. Cre mediated recombination deleted exon 1 leaving the neo cassette insertion intact. RT-PCR and immunohistochemical analyses confirmed the absence of mRNA and protein expression in cartilage from homozygous mice. (J:184281)

Expression

In Mice Carrying this Mutation:	38 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frzb Mutation: 23 strains or lines available

References

• Original: J:184281 Lories RJ, et al., Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum. 2007 Dec;56(12):4095-103
• All: 5 reference(s)