Dzip1l^{tm1a(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Dzip1l^{tm1a(KOMP)Wtsi}
• Name: DAZ interacting protein 1-like; targeted mutation 1a, Wellcome Trust Sanger Institute
• MGI ID: MGI:5319839
• Gene: Dzip1l Location: Chr9:99511549-99551309 bp, + strand Genetic Position: Chr9, 51.93 cM, cytoband F1
• IMPC: Dzip1l gene page

Mutation origin

• Mutant Cell Lines: EPD0266_1_A01, EPD0266_1_E02, EPD0266_1_F01
• Germline Transmission: Unknown
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Pgk_PM
• Mutation details: The L1L2_Pgk_PM cassette was inserted at position 99521377 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 99522215. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Dzip1l Mutation: 30 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 2 reference(s)