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Dock2m1Hsd
Spontaneous Allele Detail
Nomenclature
Symbol: Dock2m1Hsd
Name: dedicator of cyto-kinesis 2; mutation 1, Harlan
MGI ID: MGI:5319388
Synonyms: Dock2Hsd, Dock2mu
Gene: Dock2  Location: Chr11:34226815-34783892 bp, - strand  Genetic Position: Chr11, 19.68 cM, cytoband A5
Mutation
origin
Strain of Origin:  C57BL/6NHsd
Mutation
description
Allele Type:    Spontaneous
Mutations:    Duplication, Nucleotide substitutions
  Dock2m1Hsd involves 1 genes/genome features (Dock2) View all
 
Mutation detailsA spontaneous mutation generated a duplication of exons 28 and 29 and frameshift mutation (AAC to TGA) after exon 29. RT-PCR confirmed the reduction in transcript expression in bone marrow cells and splenocytes. This duplication is present in C57BL/6NHsd but not C57BL/6NClr, C57BL/6NJ or C57BL/6NTac. (J:182658, J:231437)
Schematic showing the duplication and location of the premature stop codon in the Dock2m1Hsd allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dock2 Mutation:  86 strains or lines available
Notes
Dock2mu was confirmed to be present in two Irf5tm1Ttg lines from the USA backcrossed using C57BL/6NHsd but not one line from Japan. J:182658 J:231437
References
Original:  J:182658 Purtha WE, et al., Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E898-904
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory