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Spontaneous Allele Detail
Symbol: Dock2m1Hsd
Name: dedicator of cyto-kinesis 2; mutation 1, Harlan
MGI ID: MGI:5319388
Synonyms: Dock2Hsd, Dock2mu
Gene: Dock2  Location: Chr11:34226815-34783892 bp, - strand  Genetic Position: Chr11, 19.68 cM, cytoband A5
Strain of Origin:  C57BL/6NHsd
Allele Type:    Spontaneous
Mutations:    Duplication, Nucleotide substitutions
  Dock2m1Hsd involves 1 genes/genome features (Dock2) View all
Mutation detailsA spontaneous mutation generated a duplication of exons 28 and 29 and frameshift mutation (AAC to TGA) after exon 29. RT-PCR confirmed the reduction in transcript expression in bone marrow cells and splenocytes. This duplication is present in C57BL/6NHsd but not C57BL/6NClr, C57BL/6NJ or C57BL/6NTac. (J:182658, J:231437)
Schematic showing the duplication and location of the premature stop codon in the Dock2m1Hsd allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dock2 Mutation:  86 strains or lines available
Dock2mu was confirmed to be present in two Irf5tm1Ttg lines from the USA backcrossed using C57BL/6NHsd but not one line from Japan. J:182658 J:231437
Original:  J:182658 Purtha WE, et al., Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E898-904
All:  7 reference(s)

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MGI 6.13
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