Dock2^m1Hsd
Spontaneous Allele Detail

Summary

• Symbol: Dock2^m1Hsd
• Name: dedicator of cyto-kinesis 2; mutation 1, Harlan
• MGI ID: MGI:5319388
• Synonyms: Dock2^Hsd, Dock2^mu
• Gene: Dock2 Location: Chr11:34176815-34674719 bp, - strand Genetic Position: Chr11, 19.68 cM, cytoband A5
• Alliance: Dock2^m1Hsd page

Mutation origin

• Strain of Origin: C57BL/6NHsd

Mutation description

Allele Type: Spontaneous Mutations: Duplication, Nucleotide substitutions Dock2^m1Hsd involves 1 genes/genome features (Dock2) View all Mutation details: A spontaneous mutation generated a duplication of exons 28 and 29 and frameshift mutation (AAC to TGA) after exon 29. RT-PCR confirmed the reduction in transcript expression in bone marrow cells and splenocytes. This duplication is present in C57BL/6NHsd but not C57BL/6NClr, C57BL/6NJ or C57BL/6NTac. (J:182658, J:231437)

Schematic showing the duplication and location of the premature stop codon in the Dock2^m1Hsd allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock2 Mutation: 142 strains or lines available

Notes

Dock2^mu was confirmed to be present in two Irf5^tm1Ttg lines from the USA backcrossed using C57BL/6NHsd but not one line from Japan. J:182658 J:231437

References

• Original: J:182658 Purtha WE, et al., Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E898-904
• All: 8 reference(s)