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Targeted Allele Detail
Symbol: Fbxo4tm1Kei
Name: F-box protein 4; targeted mutation 1, Keiichi I Nakayama
MGI ID: MGI:5319202
Gene: Fbxo4  Location: Chr15:3965445-3979573 bp, - strand  Genetic Position: Chr15, 1.84 cM, cytoband A1
Germline Transmission:  Earliest citation of germline transmission: J:183656
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn IRES-lacZ/neo cassette replaced exon 1 (downstream of the translation initiation site) through exon 5. RT-PCR confirmed the absence of transcript expression in mouse embryonic fibroblasts. (J:183656)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fbxo4 Mutation:  13 strains or lines available
Original:  J:183656 Kanie T, et al., Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol Cell Biol. 2012 Feb;32(3):590-605
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory