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Tigartm1.2Smat
Targeted Allele Detail
Nomenclature
Symbol: Tigartm1.2Smat
Name: Trp53 induced glycolysis regulatory phosphatase; targeted mutation 1.2, Satoaki Matoba
MGI ID: MGI:5319187
Gene: Tigar  Location: Chr6:127085116-127109552 bp, - strand  Genetic Position: Chr6, 61.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183674
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression in the heart. (J:183674)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tigar Mutation:  42 strains or lines available
References
Original:  J:183674 Hoshino A, et al., p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol. 2012 Jan;52(1):175-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory