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Cul7tm2.1Jdec
Targeted Allele Detail
Nomenclature
Symbol: Cul7tm2.1Jdec
Name: cullin 7; targeted mutation 2.1,
MGI ID: MGI:5318992
Synonyms: p1852loxP
Gene: Cul7  Location: Chr17:46961264-46975290 bp, + strand  Genetic Position: Chr17, 22.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85161
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector containing a FRT site flanked NEO cassette and a loxP site was utilized in the construction of this mutant. This selection cassette was inserted upstream of exon 2 of the targeted gene, and another loxP site was inserted downstream of exon 4. Properly targeted mice were crossed to mice expressing FLP recombinase to remove the FRT site flanked neo selection cassette. (J:85161)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cul7 Mutation:  54 strains or lines available
References
Original:  J:85161 Arai T, et al., Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9855-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory