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Targeted Allele Detail
Symbol: Rhagtm1Goo
Name: Rhesus blood group-associated A glycoprotein; targeted mutation 1, Dominique Goossens
MGI ID: MGI:5318589
Gene: Rhag  Location: Chr17:40811126-40840754 bp, + strand  Genetic Position: Chr17, 19.54 cM
Germline Transmission:  Earliest citation of germline transmission: J:182122
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Duplication, Insertion
  Rhagtm1Goo involves 1 genes/genome features (Rhag) View all
Mutation detailsA vector isolated from a targeting vector library described in J:115976 was used to generate this null allele. The vector consisted of an upstream portion of the Hprt gene, a loxP site, a puromycin resistance gene, and a 7.1 kb genomic fragment, including exons 2-5, in which a deletion was created. This vector was used in gap repair targeting where the genomic gap in the vector is repaired by the chromosomal DNA template, creating a duplication on the chromosome. Western blot analysis confirmed the absence of expression in homozygous mice. (J:182122)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rhag Mutation:  17 strains or lines available
Original:  J:182122 Goossens D, et al., Generation and characterisation of Rhd and Rhag null mice. Br J Haematol. 2010 Jan;148(1):161-72
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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