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Ltbrtm1.1Thhe
Targeted Allele Detail
Nomenclature
Symbol: Ltbrtm1.1Thhe
Name: lymphotoxin B receptor; targeted mutation 1.1, Thomas Hehlgans
MGI ID: MGI:5318395
Synonyms: LTbetaRflox
Gene: Ltbr  Location: Chr6:125306571-125313885 bp, - strand  Genetic Position: Chr6, 59.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183109
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the neo cassette. (J:183109)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ltbr Mutation:  4 strains or lines available
References
Original:  J:183109 Wimmer N, et al., Lymphotoxin beta receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands. J Immunol. 2012 Apr 1;188(7):3426-33
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory