About   Help   FAQ
Chemically induced Allele Detail
Symbol: b2b977Clo
Name: Mutant line 977; Bench to Bassinet Program (B2B/CVDC), mutation 227 Cecilia Lo
MGI ID: MGI:5318333
Gene: b2b977Clo  Location: unknown  
Transposition of the great arteries (TGA) confirmed by EFIC imaging in mutant 977-007-1 (E17.5)

Show the 9 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b977Clo Mutation:  1 strain or line available
Summative Diagnosis:
Double outlet right ventricle (DORV), transposition of the great arteries (TGA), myocardial non-compaction and aortic arch anomalies including interrupted aortic arch (IAA) and right aortic arch (RAA)

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0600 Double outlet right ventricle
0700 D-loop transposition of the great arteries
1250 Interrupted aortic arch
1802 Excessive myocardial trabeculation or noncompaction
2700 Abnormal aortic arch
3804 Congenital heart disease

Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory