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b2b827Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b827Clo
Name: Mutant line 827; Bench to Bassinet Program (B2B/CVDC), mutation 827 Cecilia Lo
MGI ID: MGI:5317766
Gene: b2b827Clo  Location: unknown  
Micrognathia observed in mutant 827-004-LA

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b827Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Cardiac defect phenotype: Left ventricular hypertrophy and perimembranous (pm)/muscular (m) ventricular septal defect (VSD)
Non-cardiovascular defects: Cleft palate, cleft lip, micrognathia, and anophthalmia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
1300 Ventricular septal defect
3608 Left ventricular hypertrophy
3804 Congenital heart disease
4163 Micrognathia
4401 Cleft palate and cleft lip
4864 Anophthalmia

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory