Tg(CAG-AVEN)1Zrng
Transgene Detail

Summary

• Symbol: Tg(CAG-AVEN)1Zrng
• Name: transgene insertion 1, Martin Zoernig
• MGI ID: MGI:5317427
• Synonyms: Tg(ACTB-Aven)
• Transgene: Tg(CAG-AVEN)1Zrng Location: unknown
• Alliance: Tg(CAG-AVEN)1Zrng page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-AVEN)1Zrng expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AVEN (57099)

  Aven	(MGI:1921518)

• Mutation details: The transgene comprises a full length cDNA encoding human caspase activation inhibitor (AVEN) inserted into the pCAGGS vector downstream of the "CAG promoter" -- which consists of the cytomegalovirus immediate early (CMV-EI) enhancer followed by a 1.3-kb DNA segment including the promoter, first exon and first intron of the chicken beta-actin gene with the 3' splice junction sequence replaced by that of the rabbit hemoglobin beta gene -- and followed by the rabbit beta-hemoglobin polyadenylation signal and 3' flanking sequence. Significant overexpression of AVEN is observed only in the heart. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)