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Lgi1tm1.1Ics
Targeted Allele Detail
Nomenclature
Symbol: Lgi1tm1.1Ics
Name: leucine-rich repeat LGI family, member 1; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:5317113
Gene: Lgi1  Location: Chr19:38264536-38312214 bp, + strand  Genetic Position: Chr19, 32.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182795
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 6. A floxed neo cassette was inserted downstream of exon 7. Cre-mediated recombination removed the neo cassette and exons 6 and 7. Western blot analysis confirmed the absence of protein expression in the brain and spine. (J:182795)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lgi1 Mutation:  19 strains or lines available
References
Original:  J:182795 Chabrol E, et al., Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice. Brain. 2010 Sep;133(9):2749-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory